Season the chicken on both sides with salt and pepper.
In a bowl mix flour, oregano, garlic powder, cayenne pepper (if using), salt, and pepper.
Coat the chicken in the flour, then back into the buttermilk, then finally into the flour, coat very well pressing into the chicken to make sure the breading is firmly attached.
Heat the oil in a pot or heavy-bottomed cast iron skillet on medium heat to 325°F.
Working in batches if needed, add the chicken to the hot oil and fry until golden brown on all sides to an internal temperature of 160°F is reached. (To check the internal temperature, carefully remove the chicken from the oil onto a paper towel and probe the fattest part with a thermometer.)
Once cooked, set on a paper towel to drain any excess oil.
Drizzle with hot sauce and honey. Garnish with pickle chips. Serve with sweet buns.