Prep toppings per instruction above.
Preheat the oven broiler on low.
Make the guacamole: Mash the avocado in a bowl with a fork until smooth. Mix in the remaining ingredients until fully combined. Season with salt and pepper to taste. Refrigerate until ready to serve.
Make the beef: Heat a nonstick pan over medium heat. Once hot, add the ground beef, onion powder, cumin, garlic powder, paprika, and chili powder. Break up the beef into smaller pieces using a spatula. Once the beef is no longer pink, drain any excess grease. Season with salt and pepper.
Place the tortilla chips on a baking sheet. Spoon the beef over the tortilla chips, top with all the cheeses, along with refried beans. Broil until the cheese has melted.
Make margarita: Place all ingredients into a pitcher or drink shaker. Mix until the honey is dissolved and everything is mixed well. Adjust any of the ingredients as needed to taste.
Serve: Remove nachos from oven and top with lettuce, tomato, jalapeno (if using), onion, sour cream, and guacamole. Enjoy with margarita served over ice.