Preheat a non-stick pan or panini style grill, over medium heat.
In a bowl, whisk the mayo, chipotle, and honey. Season with salt and pepper. Spread the mixture on both slices of bread or put on the side if desired.
Cover both slices of bread with brie. Layer with apple, spring mix, and ham. Then put the two slices together.
If using a panini style grill, lightly spray with non-stick spray and cook the sandwich until it is golden brown and cheese is melted. (If using a pan on the stovetop, add about a teaspoon of oil or more if needed, then the sandwich and cover with a lid. Cook on both sides until the bread is golden brown and the cheese is melted.)